CD109

Across TCGA cell cohorts, CD109 mutation is significantly associated with the RNA expression of many other genes, with 227 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CD109-associated genes across cancer lineages are TMEM174, TEK, and DAZ4. Each is linked with CD109 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD109-to-partner and partner-to-CD109 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM174 grouped by CD109-low versus CD109-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD109→partner) and Y-score (partner→CD109) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TMEM174 →	+0.014	+4.672	<.001	.002	3	2
BLOOD_Myeloma	TEK →	+0.315	+3.906	.006	.009	3	1
BLOOD_Myeloma	DAZ4 →	+1.634	+4.285	<.001	.003	3	1
OESOPHAGUS	SMIM43 →	+0.143	+4.017	.001	.007	3	1
OESOPHAGUS	OR1J4 →	+0.192	+4.017	<.001	.007	3	1
LUNG_NSCLC_LUAD	CST11 →	+0.151	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 227 associations by consensus.

TMEM174 by CD109 expression — BREAST

Explore this box plot interactively →