CD109

Across TCGA pan-cancer cohorts, CD109 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CD109’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CD109 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CD109 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where CD109 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CD109 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.030	<.001	12	view →
KICH	Male	II,III,IV	−2.462	<.001	11	view →
KIRC	Male	IV	+1.809	<.001	11	view →
THCA	Male	All	+1.525	<.001	9	view →
LIHC	Male	All	+1.674	<.001	8	view →
LUSC	Male	II,III,IV	+1.629	<.001	6	view →
READ	All	III,IV	+0.639	<.001	4	view →
PAAD	All	All	+1.672	.037	2	view →
UCEC	All	All	−1.333	.009	2	view →
KIRP	All	IV	−1.089	.024	2	view →
BRCA	All	IV	+1.040	.043	2	view →
READ	Female	All	−2.001	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CD109–HNSC

Open the HNSC breakdown →