CCNQ

Across TCGA patient cohorts, CCNQ mutation is significantly associated with the RNA expression of many other genes, with 845 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNQ-associated genes across cancer lineages are PAGE3, MIR153-2, and RN7SKP213. Each is linked with CCNQ in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNQ-to-partner and partner-to-CCNQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAGE3 grouped by CCNQ-low versus CCNQ-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNQ→partner) and Y-score (partner→CCNQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PAGE3 →	+0.235	+5.506	<.001	.005	3	2
BRCA	MIR153-2 →	+0.566	+5.148	<.001	.008	3	2
SKCM	RN7SKP213 →	+0.115	+3.533	.002	.007	3	2
LUSC	RNU6-1270P →	+0.388	+7.924	<.001	.008	3	2
BRCA	MRPS31P1 →	+0.229	+6.324	.001	.001	3	1
BRCA	DHFRP3 →	+0.061	+6.112	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 845 associations by consensus.

PAGE3 by CCNQ expression — BRCA

Explore this box plot interactively →