Q-omics provides the consensus-scored MIR153-2 profile across patient tissues and cancer cell-line models. MIR153-2 expression is associated with patient survival in 6 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, MIR153-2 is differentially expressed in 2, with the highest sampling consensus in COAD. Additionally, MIR153-2 RNA expression shows 7,152 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRC, COAD, and GBM as cancer lineages where MIR153-2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR153-2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR153-2 survival associations across molecular data types. MIR153-2 RNA expression shows survival associations in the most cancer types (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR153-2 RNA expression–survival associations across cancer types. High MIR153-2 expression shows unfavorable associations in KIRC, SKCM, LIHC, DLBC, TGCT and BLCA. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .005). Together, the overview and detailed table identify KIRC as the clearest survival context for MIR153-2 RNA expression.
This table summarizes MIR153-2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for MIR153-2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR153-2 shows higher tumor expression in COAD and BRCA. The COAD box plot shows higher MIR153-2 RNA expression in tumor versus normal tissue (log2 FC = +0.096, t-test p = .040).
This table shows molecular features associated with MIR153-2 in patient tissues and cancer cell lines. In patient samples, MIR153-2 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
