CCNO

Across TCGA cell cohorts, CCNO mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCNO-associated genes across cancer lineages are GKN1, SLC15A5, and TBC1D3. Each is linked with CCNO in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNO-to-partner and partner-to-CCNO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GKN1 grouped by CCNO-low versus CCNO-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNO→partner) and Y-score (partner→CCNO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GKN1 →	+0.063	+4.095	<.001	.009	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TBC1D3 →	+0.123	+4.273	<.001	.006	3	1
LUNG_NSCLC_LUAD	SSMEM1 →	+0.058	+3.906	<.001	.002	3	1
LUNG_NSCLC_LUAD	IQCA1L →	+0.037	+3.882	.008	.003	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GKN1 by CCNO expression — LARGE_INTESTINE

Explore this box plot interactively →