CCNL1

Across TCGA patient cohorts, CCNL1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNL1-associated genes across cancer lineages are INPP4B, mTOR_pS2448, and Notch1. Each is linked with CCNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNL1-to-partner and partner-to-CCNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by CCNL1-low versus CCNL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNL1→partner) and Y-score (partner→CCNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.246	-1.847	.020	.007	3	2
UCEC	mTOR_pS2448 →	-0.120	-2.209	.014	.009	3	2
UCEC	Notch1 →	+0.127	+1.687	.006	.013	3	2
UCEC	TFRC →	+0.557	+1.938	.001	.001	3	2
UCEC	ASNS →	+0.391	+2.000	.001	.009	3	2
UCEC	4E-BP1 →	+0.429	+3.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

INPP4B by CCNL1 expression — UCEC

Explore this box plot interactively →