CCL22

Across TCGA patient cohorts, CCL22 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCL22-associated genes across cancer lineages are MIR6765, MIR4418, and MIR4734. Each is linked with CCL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCL22-to-partner and partner-to-CCL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6765 grouped by CCL22-low versus CCL22-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCL22→partner) and Y-score (partner→CCL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MIR6765 →	+0.327	+4.928	<.001	.005	3	2
COAD	MIR4418 →	+1.139	+5.893	<.001	.002	3	2
UCEC	MIR4734 →	+0.663	+3.809	<.001	.007	3	1
BLCA	DEFB107B →	+0.074	+7.640	<.001	.009	3	1
SKCM	RN7SKP14 →	+0.133	+6.993	<.001	<.001	3	1
SKCM	EIF4A2P5 →	+0.089	+6.080	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MIR6765 by CCL22 expression — STAD

Explore this box plot interactively →