CCL21

Across TCGA cell cohorts, CCL21 RNA expression is significantly associated with the go_rna of many other GO terms, with 471 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CCL21-associated GO terms across cancer lineages are Membrane raft localization, CUT catabolic process, and Mesonephric duct development. Each is linked with CCL21 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCL21-to-partner and partner-to-CCL21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane raft localization grouped by CCL21-low versus CCL21-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCL21→partner) and Y-score (partner→CCL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Membrane raft localization →	+0.202	+0.031	<.001	.009	3	3
SKIN	CUT catabolic process →	+0.113	+0.036	<.001	.001	3	3
SKIN	Mesonephric duct development →	-0.275	-0.033	<.001	.002	3	3
LUNG_SCLC	Bile acid and bile salt transport →	-0.070	-0.023	.005	.001	3	3
SKIN	Mitochondrial potassium ion transmembrane transport →	-0.159	-0.064	<.001	.001	3	3
SKIN	Actomyosin contractile ring assembly actin filament organization →	-0.161	-0.033	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 471 associations by consensus.

Membrane raft localization by CCL21 expression — LARGE_INTESTINE

Explore this box plot interactively →