CCL21

Across TCGA pan-cancer cohorts, CCL21 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CCL21 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CCL21 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CCL21 expression acts as an unfavorable survival marker, although some lineages such as CESC and BRCA show a favorable association.

KIRP, CESC, and LUSC are the cancer types where CCL21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.594	0.886	.001	59	view →
CESC	OS	Tertile	II,III,IV	0.909	0.645	<.001	42	view →
LUSC	OS	Quartile	All	0.376	0.540	.010	41	view →
BRCA	OS	Tertile	All	0.977	0.945	.001	32	view →
UVM	DFS	Median	III,IV	0.896	0.476	.003	19	view →
LIHC	DFS	Quartile	All	0.452	0.258	<.001	19	view →
MESO	DFS	Quartile	II,III,IV	0.667	0.145	.006	18	view →
LUAD	DFS	Quartile	IV	0.392	0.787	.019	13	view →
HNSC	DFS	Quartile	II,III,IV	0.766	0.622	.013	12	view →
LAML	DFS	Median	All	0.718	0.442	.007	12	view →
COAD	OS	Median	All	0.874	0.742	.020	10	view →
THCA	OS	Tertile	II,III,IV	0.966	1.000	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CCL21–KIRP (OS)

Open the KIRP breakdown →