CCL21

Across TCGA pan-cancer cohorts, CCL21 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CCL21’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CCL21 RNA is repressed in tumor relative to normal tissue. In most cancer types CCL21 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

THCA, BLCA, and COAD are the cancer types where CCL21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCL21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−7.236	<.001	11	view →
BLCA	All	III,IV	−2.700	.001	9	view →
COAD	Male	All	−2.421	<.001	9	view →
KIRC	Male	II,III,IV	−2.029	<.001	9	view →
UCEC	All	III,IV	−6.213	<.001	8	view →
BRCA	Female	II,III,IV	−3.317	<.001	6	view →
HNSC	Male	All	−1.928	<.001	6	view →
LIHC	All	All	−1.701	<.001	6	view →
KIRP	Male	All	−2.551	<.001	5	view →
LUSC	Male	All	−1.808	<.001	5	view →
STAD	Male	All	−1.461	.008	4	view →
LUAD	All	All	−0.928	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CCL21–THCA

Open the THCA breakdown →