CCL20

Across TCGA patient cohorts, CCL20 mutation is significantly associated with the RNA expression of many other genes, with 178 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCL20-associated genes across cancer lineages are MIR548AP, SEPTIN14P19, and MIR6784. Each is linked with CCL20 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCL20-to-partner and partner-to-CCL20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548AP grouped by CCL20-low versus CCL20-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCL20→partner) and Y-score (partner→CCL20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR548AP →	+0.317	+8.055	<.001	.007	3	1
UCEC	SEPTIN14P19 →	+0.028	+4.075	<.001	.007	3	1
UCEC	MIR6784 →	+1.043	+3.875	<.001	<.001	3	1
UCEC	CYB5R3 →	+0.646	+3.329	.002	.005	3	1
UCEC	ACD →	+0.679	+3.354	<.001	.005	3	1
UCEC	HMOX2 →	+0.547	+3.393	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 178 associations by consensus.

MIR548AP by CCL20 expression — BRCA

Explore this box plot interactively →