CCL20

Across TCGA pan-cancer cohorts, CCL20 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CCL20 data layer compared with 2 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CCL20 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCL20 expression acts as an unfavorable survival marker, although some lineages such as UCS and LUSC show a favorable association.

KIRP, UVM, and LUAD are the cancer types where CCL20 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.458	0.799	<.001	121	view →
UVM	DFS	Quartile	II,III,IV	0.308	0.698	<.001	106	view →
LUAD	OS	Tertile	All	0.252	0.405	<.001	63	view →
ACC	OS	Median	II,III,IV	0.753	0.937	<.001	62	view →
LIHC	OS	Tertile	All	0.618	0.796	.003	47	view →
KICH	OS	Tertile	II,III,IV	0.731	1.000	.003	44	view →
BRCA	OS	Tertile	III,IV	0.732	0.902	.001	40	view →
HNSC	OS	Median	III,IV	0.591	0.716	.013	33	view →
LGG	DFS	Tertile	All	0.376	0.529	.002	31	view →
CESC	OS	Median	All	0.829	0.916	.013	26	view →
UCS	DFS	Tertile	IV	0.821	0.239	.024	24	view →
LUSC	DFS	Quartile	III,IV	0.717	0.371	.005	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CCL20–KIRP (DFS)

Open the KIRP breakdown →