CCDC83

Across TCGA patient cohorts, CCDC83 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC83-associated genes across cancer lineages are Cyclin-E2, 14-3-3_beta, and EGFR_pY1068. Each is linked with CCDC83 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC83-to-partner and partner-to-CCDC83 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by CCDC83-low versus CCDC83-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC83→partner) and Y-score (partner→CCDC83) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.176	+2.331	.004	.003	3	3
UCEC	14-3-3_beta →	-0.077	-2.432	.036	.018	3	1
UCEC	EGFR_pY1068 →	-0.215	-2.584	.019	.010	3	1
UCEC	eIF4G →	+0.257	+1.847	.024	.008	3	1
UCEC	FoxM1 →	+0.292	+2.736	.002	<.001	2	2
UCEC	ACVRL1 →	-0.116	-1.787	.020	.026	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Cyclin-E2 by CCDC83 expression — UCEC

Explore this box plot interactively →