CCDC8

Across TCGA patient cohorts, CCDC8 mutation is significantly associated with the RNA expression of many other genes, with 3,029 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC8-associated genes across cancer lineages are MRGPRX6P, C18orf25, and PPM1D. Each is linked with CCDC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC8-to-partner and partner-to-CCDC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRX6P grouped by CCDC8-low versus CCDC8-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC8→partner) and Y-score (partner→CCDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MRGPRX6P →	+0.039	+4.584	<.001	.004	3	3
UCEC	C18orf25 →	+0.475	+2.595	<.001	.005	3	3
UCEC	PPM1D →	+0.426	+3.815	.002	<.001	3	3
GBM	MIR5787 →	+1.166	+5.857	<.001	.002	3	2
UCEC	IGHV2-70 →	+1.471	+3.807	.001	<.001	3	2
UCEC	TUBGCP5 →	+0.416	+2.595	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,029 associations by consensus.

MRGPRX6P by CCDC8 expression — LIHC

Explore this box plot interactively →