CCDC8

Across TCGA pan-cancer cohorts, CCDC8 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CCDC8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CCDC8 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC8 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and UCEC are the cancer types where CCDC8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−2.316	<.001	11	view →
THCA	Male	All	−1.074	<.001	8	view →
UCEC	All	All	−2.058	<.001	6	view →
BRCA	Female	All	−1.852	<.001	6	view →
HNSC	All	All	+0.892	.006	6	view →
LUAD	All	All	−0.660	<.001	6	view →
KICH	Male	All	−2.151	<.001	5	view →
CHOL	All	All	+1.699	.002	5	view →
PRAD	All	All	−1.380	<.001	2	view →
BLCA	Male	All	−1.185	.036	2	view →
KIRP	All	All	−0.966	.006	2	view →
COAD	Female	II,III,IV	−0.472	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CCDC8–KIRC

Open the KIRC breakdown →