CCDC71

Across TCGA patient cohorts, CCDC71 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC71-associated genes across cancer lineages are mTOR_pS2448, PRDX1, and 4E-BP1. Each is linked with CCDC71 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC71-to-partner and partner-to-CCDC71 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by CCDC71-low versus CCDC71-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC71→partner) and Y-score (partner→CCDC71) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.212	-3.150	.002	.019	3	2
UCEC	PRDX1 →	+0.204	+3.000	.034	.036	3	2
UCEC	4E-BP1 →	+0.423	+3.029	<.001	.018	3	2
UCEC	eIF4E →	+0.226	+2.584	.021	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.214	-3.169	.006	.019	3	1
UCEC	MEK1 →	+0.357	+3.321	.036	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

mTOR_pS2448 by CCDC71 expression — UCEC

Explore this box plot interactively →