CCDC68

Across TCGA patient cohorts, CCDC68 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC68-associated genes across cancer lineages are p38-MAPK_pT180_Y182, VHL, and Caspase-8. Each is linked with CCDC68 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC68-to-partner and partner-to-CCDC68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by CCDC68-low versus CCDC68-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC68→partner) and Y-score (partner→CCDC68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.444	-1.752	.008	.014	3	2
UCEC	VHL →	-0.989	-2.415	<.001	.003	3	2
UCEC	Caspase-8 →	-0.230	-3.673	.014	.001	3	2
UCEC	eIF4G →	+0.248	+1.765	.033	.014	3	1
UCEC	JNK_pT183_Y185 →	-0.203	-3.584	.001	.002	3	1
UCEC	MAPK_pT202_Y204 →	-0.385	-1.415	.029	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

p38-MAPK_pT180_Y182 by CCDC68 expression — UCEC

Explore this box plot interactively →