CCDC68

Across TCGA pan-cancer cohorts, CCDC68 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CCDC68 data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CCDC68 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CCDC68 expression acts as an unfavorable survival marker, although some lineages such as BRCA and COAD show a favorable association.

BRCA, CESC, and COAD are the cancer types where CCDC68 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.971	0.926	<.001	75	view →
CESC	DFS	Quartile	All	0.403	0.709	<.001	62	view →
COAD	DFS	Tertile	II,III,IV	0.572	0.312	<.001	62	view →
READ	DFS	Quartile	All	0.843	0.349	.002	61	view →
LUSC	OS	Quartile	All	0.710	0.849	<.001	55	view →
UVM	OS	Quartile	All	0.825	0.328	<.001	51	view →
PAAD	OS	Tertile	All	0.262	0.557	<.001	45	view →
KIRC	OS	Median	All	0.912	0.835	<.001	42	view →
SKCM	OS	Tertile	III,IV	0.539	0.333	.006	35	view →
LGG	DFS	Tertile	All	0.882	0.781	.004	27	view →
TGCT	DFS	Median	All	0.734	0.929	.004	16	view →
MESO	DFS	Tertile	All	0.451	0.286	.028	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CCDC68–BRCA (DFS)

Open the BRCA breakdown →