CCDC68

Across TCGA pan-cancer cohorts, CCDC68 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CCDC68’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CCDC68 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC68 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and KIRC are the cancer types where CCDC68 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC68 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−2.402	<.001	11	view →
LUSC	Female	II,III,IV	−3.234	<.001	8	view →
KIRC	Male	IV	+1.052	<.001	8	view →
THCA	All	II,III,IV	−0.620	<.001	8	view →
LUAD	Female	III,IV	−1.759	<.001	7	view →
BRCA	All	All	−0.720	<.001	6	view →
READ	All	All	−2.173	<.001	5	view →
KICH	All	All	+1.298	<.001	5	view →
UCEC	All	All	−1.131	<.001	4	view →
CHOL	All	All	+1.021	.017	2	view →
PRAD	All	All	−0.484	<.001	2	view →
STAD	Male	II,III,IV	+0.951	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CCDC68–COAD

Open the COAD breakdown →