CCDC54

Across TCGA patient cohorts, CCDC54 mutation is significantly associated with the RNA expression of many other genes, with 1,671 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC54-associated genes across cancer lineages are LINGO1-AS2, ENSAP1, and RTCB. Each is linked with CCDC54 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC54-to-partner and partner-to-CCDC54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINGO1-AS2 grouped by CCDC54-low versus CCDC54-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC54→partner) and Y-score (partner→CCDC54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINGO1-AS2 →	+0.201	+4.666	<.001	.005	3	3
LIHC	ENSAP1 →	+0.144	+6.149	<.001	.002	3	2
UCEC	RTCB →	+0.548	+3.513	.002	.002	3	2
UCEC	SEC24D →	+0.762	+2.233	.001	.006	3	2
COAD	VN1R3 →	+0.400	+5.557	<.001	.001	3	2
LUAD	OR10T2 →	+0.015	+4.140	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,671 associations by consensus.

LINGO1-AS2 by CCDC54 expression — COAD

Explore this box plot interactively →