CCDC54

Across TCGA pan-cancer cohorts, CCDC54 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CCDC54’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CCDC54 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC54 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and KIRC are the cancer types where CCDC54 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC54 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.265	<.001	11	view →
LUAD	Male	II,III,IV	−0.457	<.001	9	view →
KIRC	All	All	−0.062	<.001	7	view →
BRCA	Female	All	−0.100	.003	4	view →
LUSC	Female	All	−0.356	<.001	3	view →
LIHC	All	All	+0.044	.001	3	view →
PRAD	All	All	−0.333	<.001	2	view →
BLCA	All	IV	−0.100	.014	2	view →
KICH	All	All	−0.080	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CCDC54–THCA

Open the THCA breakdown →