CCDC38

Across TCGA patient cohorts, CCDC38 mutation is significantly associated with the RNA expression of many other genes, with 1,814 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC38-associated genes across cancer lineages are CHEK2P1, RNA5SP198, and RPL17P2. Each is linked with CCDC38 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC38-to-partner and partner-to-CCDC38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK2P1 grouped by CCDC38-low versus CCDC38-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC38→partner) and Y-score (partner→CCDC38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CHEK2P1 →	+0.142	+4.736	<.001	.007	3	2
UCEC	RNA5SP198 →	+0.287	+2.373	.002	.009	3	2
UCEC	RPL17P2 →	+0.092	+2.056	.007	.001	3	2
UCEC	RNA5SP402 →	+0.332	+1.774	.001	.009	3	2
HNSC	TUBB1P2 →	+0.038	+5.111	<.001	.004	3	2
HNSC	SGCEP1 →	+0.049	+4.822	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,814 associations by consensus.

CHEK2P1 by CCDC38 expression — HNSC

Explore this box plot interactively →