CCDC38

Across TCGA pan-cancer cohorts, CCDC38 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CCDC38’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CCDC38 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC38 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, HNSC, and THCA are the cancer types where CCDC38 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC38 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.225	<.001	10	view →
HNSC	Male	IV	+0.323	<.001	8	view →
THCA	Male	III,IV	−0.091	<.001	7	view →
BRCA	All	III,IV	−0.149	<.001	6	view →
KIRC	All	II,III,IV	+0.097	.002	6	view →
CHOL	Male	All	−0.608	<.001	5	view →
BLCA	All	All	+0.087	.023	2	view →
LUAD	Female	II,III,IV	−0.086	.004	2	view →
UCEC	All	All	−0.074	.043	2	view →
LUSC	Female	III,IV	−0.225	.006	1	view →
LUSC	All	All	+0.120	.042	1	view →
ESCA	Female	All	−0.066	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

CCDC38–KICH

Open the KICH breakdown →