CCDC33

Across TCGA cell cohorts, CCDC33 mutation is significantly associated with the mutation status of many other genes, with 4,800 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC33-associated genes across cancer lineages are ADGB, KSR2, and PCDHGB1. Each is linked with CCDC33 in more than 4 cancer types. Because this analysis shows association rather than direction, both CCDC33-to-partner and partner-to-CCDC33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADGB grouped by CCDC33-low versus CCDC33-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC33→partner) and Y-score (partner→CCDC33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ADGB →	+5.000	+4.437	.007	.007	1	5
BONE	KSR2 →	+5.000	+4.437	.007	.007	1	5
BREAST	PCDHGB1 →	+4.297	+4.857	.009	.009	1	5
BLOOD_Leukemia	ITGB4 →	+2.730	+4.037	<.001	<.001	1	5
BLOOD_Leukemia	DCHS2 →	+2.167	+3.017	.003	.003	1	5
BONE	INSRR →	+5.000	+4.437	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,800 associations by consensus.

ADGB by CCDC33 expression — BONE

Explore this box plot interactively →