CCDC33

Across TCGA pan-cancer cohorts, CCDC33 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CCDC33’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CCDC33 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC33 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

KIRC, LUSC, and LUAD are the cancer types where CCDC33 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC33 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.048	<.001	12	view →
LUSC	All	II,III,IV	−1.329	<.001	8	view →
LUAD	Female	All	−0.957	<.001	8	view →
CHOL	All	II,III,IV	+0.329	.008	4	view →
COAD	All	All	+0.049	.001	4	view →
KICH	All	All	+0.215	.005	3	view →
READ	All	III,IV	+0.130	.022	2	view →
ESCA	All	II,III,IV	+0.085	.016	2	view →
THCA	All	All	+0.082	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CCDC33–KIRC

Open the KIRC breakdown →