CCDC24

Across TCGA patient cohorts, CCDC24 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC24-associated genes across cancer lineages are EGFR, MEK1, and Annexin-1. Each is linked with CCDC24 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC24-to-partner and partner-to-CCDC24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by CCDC24-low versus CCDC24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC24→partner) and Y-score (partner→CCDC24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.206	-3.169	.005	.019	3	1
UCEC	MEK1 →	+0.353	+2.584	.038	.011	3	1
UCEC	Annexin-1 →	+0.580	+2.827	.018	.035	3	1
UCEC	Chk2 →	-0.247	-2.321	.023	.034	3	1
UCEC	INPP4B →	-0.320	-3.000	.033	.036	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

EGFR by CCDC24 expression — UCEC

Explore this box plot interactively →