CCDC22

Across TCGA cell cohorts, CCDC22 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCDC22-associated genes across cancer lineages are SCN10A, TRIM64B, and EPPIN. Each is linked with CCDC22 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC22-to-partner and partner-to-CCDC22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCN10A grouped by CCDC22-low versus CCDC22-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC22→partner) and Y-score (partner→CCDC22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SCN10A →	+0.063	+5.029	<.001	.006	3	1
LUNG_SCLC	TRIM64B →	+0.034	+5.029	.003	.006	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	OR52L1 →	+0.045	+5.201	<.001	.006	3	1
BLOOD_Leukemia	MBD3L4 →	+0.013	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SCN10A by CCDC22 expression — LUNG_SCLC

Explore this box plot interactively →