Across TCGA patient cohorts, CCDC190 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC190-associated genes across cancer lineages are HER3, Acetyl-a-Tubulin-Lys40, and INPP4B. Each is linked with CCDC190 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC190-to-partner and partner-to-CCDC190 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC190→partner) and Y-score (partner→CCDC190) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3 →	+0.381	+2.820	.002	.035	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.647	+2.584	.006	.011	3	1
UCEC	INPP4B →	-0.415	-2.571	.005	.011	3	1
UCEC	MEK1 →	+0.532	+3.321	.001	.010	3	1
UCEC	mTOR →	-0.294	-3.000	<.001	.036	2	2
UCEC	Notch1 →	+0.158	+2.817	.016	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

CCDC190 survival (RNA) · tumor vs normal (RNA) · all CCDC190 data types