CCDC181

Across TCGA patient cohorts, CCDC181 mutation is significantly associated with the RNA expression of many other genes, with 2,921 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC181-associated genes across cancer lineages are RNA5SP412, IGKV1D-13, and SNU13. Each is linked with CCDC181 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC181-to-partner and partner-to-CCDC181 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by CCDC181-low versus CCDC181-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC181→partner) and Y-score (partner→CCDC181) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.472	+1.645	<.001	.008	3	3
UCEC	IGKV1D-13 →	+1.429	+4.049	<.001	<.001	3	2
UCEC	SNU13 →	+0.277	+1.960	.002	.001	3	2
UCEC	MIEF1 →	+0.415	+2.923	.002	<.001	3	2
UCEC	TXN2 →	+0.398	+2.681	<.001	<.001	3	2
UCEC	FAM118A →	+0.424	+2.212	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,921 associations by consensus.

RNA5SP412 by CCDC181 expression — UCEC

Explore this box plot interactively →