CCDC181

Across TCGA pan-cancer cohorts, CCDC181 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated CCDC181 data layer compared with 9 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher CCDC181 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCDC181 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

LGG, ACC, and STAD are the cancer types where CCDC181 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.659	0.818	<.001	50	view →
ACC	DFS	Quartile	All	0.518	0.916	.001	46	view →
STAD	DFS	Quartile	II,III,IV	0.287	0.511	.001	42	view →
UCS	OS	Quartile	II,III,IV	0.919	0.415	.002	36	view →
SKCM	OS	Median	III,IV	0.510	0.270	.003	27	view →
LUAD	OS	Tertile	All	0.550	0.257	.002	22	view →
LAML	DFS	Quartile	All	0.591	0.222	.001	22	view →
LIHC	DFS	Quartile	All	0.407	0.595	<.001	21	view →
SARC	OS	Median	All	0.423	0.586	.002	14	view →
UCEC	DFS	Quartile	All	0.509	0.743	.002	12	view →
THCA	DFS	Median	All	0.893	0.757	.003	11	view →
KIRC	DFS	Median	IV	0.505	0.721	.003	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

CCDC181–LGG (DFS)

Open the LGG breakdown →