CCDC181

Across TCGA pan-cancer cohorts, CCDC181 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CCDC181’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CCDC181 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC181 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and UCEC are the cancer types where CCDC181 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC181 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.271	<.001	12	view →
KICH	All	IV	−3.022	<.001	11	view →
UCEC	All	All	−1.929	<.001	8	view →
LUSC	Female	II,III,IV	−1.291	<.001	8	view →
LUAD	All	III,IV	−1.047	<.001	8	view →
KIRP	Male	All	−0.869	<.001	7	view →
LIHC	All	II,III,IV	+0.094	.008	5	view →
COAD	All	All	−0.119	.014	4	view →
CHOL	All	All	+0.672	.006	3	view →
READ	All	All	−0.365	.006	3	view →
PRAD	All	All	−0.641	<.001	2	view →
THCA	All	All	+0.301	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CCDC181–KIRC

Open the KIRC breakdown →