CCDC181

Across TCGA patient cohorts, CCDC181 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC181-associated genes across cancer lineages are ACC1, PDCD4, and TFRC. Each is linked with CCDC181 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC181-to-partner and partner-to-CCDC181 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by CCDC181-low versus CCDC181-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC181→partner) and Y-score (partner→CCDC181) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.272	+1.415	.046	.046	3	2
UCEC	PDCD4 →	-0.584	-2.169	<.001	.003	3	2
UCEC	TFRC →	+0.550	+2.321	.005	.034	3	2
UCEC	ATM →	-0.739	-2.794	<.001	.002	3	2
UCEC	4E-BP1 →	+0.318	+3.459	.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.294	-2.662	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ACC1 by CCDC181 expression — UCEC

Explore this box plot interactively →