CCDC181

Across TCGA cell cohorts, CCDC181 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC181-associated genes across cancer lineages are SLC22A2, CX3CR1, and C4orf50. Each is linked with CCDC181 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC181-to-partner and partner-to-CCDC181 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC22A2 grouped by CCDC181-low versus CCDC181-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC181→partner) and Y-score (partner→CCDC181) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC22A2 →	+0.084	+3.923	<.001	.001	3	2
SKIN	CX3CR1 →	+0.052	+3.378	<.001	.001	3	1
SKIN	C4orf50 →	+0.010	+3.099	.007	.002	3	1
SKIN	MARCHF11 →	+0.195	+3.378	<.001	.001	3	1
SKIN	ARMS2 →	+0.109	+3.464	<.001	.004	3	1
LARGE_INTESTINE	PLA2G3 →	+1.392	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

SLC22A2 by CCDC181 expression — SKIN

Explore this box plot interactively →