CCDC177

Across TCGA patient cohorts, CCDC177 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC177-associated genes across cancer lineages are RNU4-35P, RNA5SP263, and RNA5SP359. Each is linked with CCDC177 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC177-to-partner and partner-to-CCDC177 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-35P grouped by CCDC177-low versus CCDC177-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC177→partner) and Y-score (partner→CCDC177) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-35P →	+0.274	+3.453	.005	.009	3	1
UCEC	RNA5SP263 →	+1.290	+4.335	<.001	.007	3	1
UCEC	RNA5SP359 →	+1.003	+3.638	<.001	.006	3	1
UCEC	RNA5SP173 →	+1.051	+4.582	<.001	.005	3	1
UCEC	RNA5SP267 →	+1.883	+3.759	<.001	.005	3	1
UCEC	RNA5SP455 →	+0.550	+5.470	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

RNU4-35P by CCDC177 expression — UCEC

Explore this box plot interactively →