CCDC177

Across TCGA pan-cancer cohorts, CCDC177 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CCDC177 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher CCDC177 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CCDC177 expression acts as an unfavorable survival marker, although some lineages such as LIHC and HNSC show a favorable association.

UVM, LIHC, and HNSC are the cancer types where CCDC177 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.396	0.759	<.001	137	view →
LIHC	OS	Tertile	All	0.792	0.595	<.001	81	view →
HNSC	DFS	Median	All	0.755	0.638	<.001	70	view →
STAD	DFS	Tertile	All	0.299	0.627	<.001	69	view →
LUSC	DFS	Quartile	All	0.839	0.692	<.001	55	view →
MESO	OS	Tertile	All	0.386	0.205	.011	39	view →
BRCA	DFS	Median	IV	0.765	0.382	.009	38	view →
ACC	OS	Median	II,III,IV	0.676	1.000	.001	38	view →
THYM	DFS	Tertile	II,III,IV	0.661	1.000	.001	31	view →
LUAD	DFS	Tertile	IV	0.371	0.790	.008	20	view →
CHOL	OS	Tertile	III,IV	0.275	0.886	.045	18	view →
PCPG	DFS	Quartile	All	0.641	0.893	.012	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CCDC177–UVM (OS)

Open the UVM breakdown →