CCDC136

Across TCGA cell cohorts, CCDC136 mutation is significantly associated with the RNA expression of many other genes, with 406 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC136-associated genes across cancer lineages are GPHA2, LRRC3C, and TEX48. Each is linked with CCDC136 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC136-to-partner and partner-to-CCDC136 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPHA2 grouped by CCDC136-low versus CCDC136-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC136→partner) and Y-score (partner→CCDC136) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GPHA2 →	+0.090	+3.944	<.001	.006	3	1
BLOOD_Leukemia	LRRC3C →	+0.097	+3.796	<.001	.008	3	1
BLOOD_Leukemia	TEX48 →	+0.039	+4.060	<.001	.003	3	1
BLOOD_Leukemia	TLE7 →	+0.025	+4.384	<.001	.006	3	1
BLOOD_Lymphoma	DCAF12L1 →	+0.012	+4.867	<.001	.009	3	1
LUNG_NSCLC_LUAD	GBX1 →	+0.685	+3.544	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 406 associations by consensus.

GPHA2 by CCDC136 expression — BLOOD_Leukemia

Explore this box plot interactively →