CCDC136

Across TCGA pan-cancer cohorts, CCDC136 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CCDC136’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CCDC136 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC136 is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

BLCA, KIRP, and UCEC are the cancer types where CCDC136 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC136 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−3.140	.001	8	view →
KIRP	All	All	+0.509	<.001	7	view →
UCEC	All	III,IV	−1.572	<.001	6	view →
BRCA	All	III,IV	−0.896	<.001	6	view →
THCA	Male	II,III,IV	−0.382	<.001	6	view →
READ	All	All	−1.201	.007	4	view →
LIHC	All	II,III,IV	+0.100	.002	4	view →
STAD	Female	All	−1.175	.018	3	view →
CHOL	All	All	+0.575	.003	3	view →
LUSC	All	All	+0.464	<.001	3	view →
PRAD	All	All	−0.659	<.001	2	view →
KICH	Female	III,IV	−0.513	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CCDC136–BLCA

Open the BLCA breakdown →