CCDC134

Across TCGA patient cohorts, CCDC134 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC134-associated genes across cancer lineages are p62 Lck ligand, p70-S6K, and PCNA. Each is linked with CCDC134 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC134-to-partner and partner-to-CCDC134 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CCDC134-low versus CCDC134-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC134→partner) and Y-score (partner→CCDC134) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.471	+3.000	.012	.037	3	1
UCEC	p70-S6K →	+0.220	+3.026	.048	.019	3	1
UCEC	PCNA →	+0.398	+3.000	.001	.037	3	1
UCEC	PDCD4 →	-0.921	-3.000	<.001	.037	3	1
UCEC	STAT3_pY705 →	-0.595	-3.000	<.001	.037	3	1
UCEC	FoxM1 →	+0.334	+3.000	.025	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

p62 Lck ligand by CCDC134 expression — UCEC

Explore this box plot interactively →