CCDC134

Across TCGA pan-cancer cohorts, CCDC134 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CCDC134 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CCDC134 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCDC134 expression acts as an unfavorable survival marker, although some lineages such as SCLC and ESCA show a favorable association.

UVM, LIHC, and SCLC are the cancer types where CCDC134 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.417	0.937	.001	71	view →
LIHC	OS	Median	All	0.418	0.609	<.001	69	view →
SCLC	DFS	Quartile	II,III,IV	0.606	0.171	<.001	63	view →
BLCA	OS	Median	II,III,IV	0.545	0.677	.006	49	view →
ESCA	OS	Tertile	II,III,IV	0.677	0.341	.001	49	view →
MESO	DFS	Quartile	All	0.240	0.467	.003	43	view →
LGG	OS	Median	All	0.742	0.882	<.001	40	view →
KIRC	DFS	Median	All	0.720	0.551	<.001	40	view →
READ	DFS	Quartile	All	0.795	0.347	.003	39	view →
ACC	DFS	Median	All	0.254	0.635	.003	35	view →
STAD	DFS	Quartile	All	0.661	0.405	<.001	35	view →
UCS	OS	Tertile	IV	0.922	0.224	.024	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CCDC134–UVM (DFS)

Open the UVM breakdown →