CCDC130

Across TCGA cell cohorts, CCDC130 mutation is significantly associated with the mutation status of many other genes, with 1,210 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCDC130-associated genes across cancer lineages are COLGALT1, MIB1, and SLC12A1. Each is linked with CCDC130 in more than 3 cancer types. Because this analysis shows association rather than direction, both CCDC130-to-partner and partner-to-CCDC130 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COLGALT1 grouped by CCDC130-low versus CCDC130-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC130→partner) and Y-score (partner→CCDC130) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	COLGALT1 →	+4.014	+4.969	.008	.008	1	4
LARGE_INTESTINE	MIB1 →	+4.044	+3.744	.003	.003	1	3
BLOOD_Lymphoma	SLC12A1 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Leukemia	PHLPP1 →	+4.157	+5.430	<.001	<.001	1	3
BLOOD_Lymphoma	ABCB1 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	PIK3CA →	+6.014	+6.014	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,210 associations by consensus.

COLGALT1 by CCDC130 expression — BLOOD_Lymphoma

Explore this box plot interactively →