CCDC130

Across TCGA pan-cancer cohorts, CCDC130 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CCDC130’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CCDC130 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCDC130 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where CCDC130 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC130 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.595	<.001	11	view →
COAD	All	IV	+0.958	<.001	10	view →
HNSC	Male	IV	+0.800	<.001	10	view →
LIHC	Female	II,III,IV	+1.386	<.001	9	view →
CHOL	All	All	+2.038	<.001	5	view →
READ	All	All	+0.811	<.001	5	view →
KICH	Female	All	−0.729	<.001	5	view →
ESCA	All	All	+0.696	<.001	5	view →
STAD	All	II,III,IV	+0.560	.003	5	view →
THCA	Male	II,III,IV	−0.404	.013	4	view →
BLCA	All	All	+0.450	.014	3	view →
KIRP	All	IV	+0.865	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CCDC130–KIRC

Open the KIRC breakdown →