CCDC113

Across TCGA patient cohorts, CCDC113 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC113-associated genes across cancer lineages are ERK2, ATM, and EGFR_pY1068. Each is linked with CCDC113 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC113-to-partner and partner-to-CCDC113 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CCDC113-low versus CCDC113-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC113→partner) and Y-score (partner→CCDC113) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.201	+1.874	.009	.049	3	2
UCEC	ATM →	-0.603	-3.446	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.338	-3.700	<.001	.001	3	1
UCEC	eIF4E →	+0.167	+1.906	.049	.016	3	1
UCEC	GAPDH →	+0.444	+3.169	.040	.018	3	1
UCEC	INPP4B →	-0.307	-3.584	.018	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ERK2 by CCDC113 expression — UCEC

Explore this box plot interactively →