CBY2

Across TCGA patient cohorts, CBY2 mutation is significantly associated with the RNA expression of many other genes, with 3,097 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CBY2-associated genes across cancer lineages are ARHGAP19, ZWILCH, and TIPIN. Each is linked with CBY2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CBY2-to-partner and partner-to-CBY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGAP19 grouped by CBY2-low versus CBY2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBY2→partner) and Y-score (partner→CBY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ARHGAP19 →	+0.750	+2.502	<.001	.001	3	4
UCEC	ZWILCH →	+0.535	+3.010	.003	<.001	3	4
UCEC	TIPIN →	+0.442	+2.343	.005	.003	3	4
SKCM	XPNPEP1 →	+0.406	+2.504	.002	<.001	3	4
SKCM	DAZAP1 →	+0.313	+2.799	<.001	.002	3	4
UCEC	BMS1P20 →	+0.432	+3.470	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,097 associations by consensus.

ARHGAP19 by CBY2 expression — SKCM

Explore this box plot interactively →