CBY2

Across TCGA pan-cancer cohorts, CBY2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CBY2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CBY2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CBY2 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

COAD, HNSC, and KICH are the cancer types where CBY2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CBY2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.545	<.001	12	view →
HNSC	Male	IV	+0.974	<.001	12	view →
KICH	Male	All	−0.698	<.001	9	view →
STAD	All	All	+0.659	<.001	8	view →
LUSC	Female	All	+1.291	<.001	7	view →
LUAD	Male	All	+0.829	<.001	7	view →
KIRP	Male	All	−0.380	<.001	7	view →
KIRC	Male	IV	−0.365	<.001	6	view →
LIHC	All	All	+0.077	<.001	5	view →
BRCA	Female	All	+0.135	.001	4	view →
READ	All	All	+0.931	.002	2	view →
BLCA	All	All	+0.595	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CBY2–COAD

Open the COAD breakdown →