CBY2

Across TCGA cell cohorts, CBY2 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CBY2-associated genes across cancer lineages are ODF1, AIRE, and RD3. Each is linked with CBY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBY2-to-partner and partner-to-CBY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ODF1 grouped by CBY2-low versus CBY2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBY2→partner) and Y-score (partner→CBY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ODF1 →	+0.016	+4.437	<.001	.004	3	1
SKIN	AIRE →	+0.213	+3.938	<.001	.005	3	1
SKIN	RD3 →	+0.030	+4.362	<.001	.005	3	1
BLOOD_Leukemia	C9 →	+1.053	+3.544	<.001	.008	3	1
BLOOD_Leukemia	C20orf85 →	+0.024	+3.969	<.001	.009	3	1
BLOOD_Leukemia	IL22 →	+0.025	+4.569	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ODF1 by CBY2 expression — SKIN

Explore this box plot interactively →