CBX6

Across TCGA patient cohorts, CBX6 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBX6-associated genes across cancer lineages are EGFR_pY1068, p62 Lck ligand, and PCNA. Each is linked with CBX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX6-to-partner and partner-to-CBX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CBX6-low versus CBX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX6→partner) and Y-score (partner→CBX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.256	-2.087	.007	.005	3	2
UCEC	p62 Lck ligand →	+0.491	+3.247	<.001	<.001	3	2
UCEC	PCNA →	+0.244	+2.115	.003	.017	3	2
UCEC	PDCD4 →	-0.465	-1.678	.009	.023	3	2
UCEC	ATM →	-0.834	-3.247	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.739	+3.479	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by CBX6 expression — UCEC

Explore this box plot interactively →