CBX6

Across TCGA cell cohorts, CBX6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,345 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CBX6-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Positive regulation of macrophage proliferation, and Interleukin-34-mediated signaling pathway. Each is linked with CBX6 in more than 13 cancer types. Because this analysis shows association rather than direction, both CBX6-to-partner and partner-to-CBX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by CBX6-low versus CBX6-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX6→partner) and Y-score (partner→CBX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of chromosome condensation →	+0.181	+1.398	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of macrophage proliferation →	+0.279	+1.499	<.001	<.001	3	13
KIDNEY	Interleukin-34-mediated signaling pathway →	+0.212	+0.920	.001	.004	3	12
KIDNEY	Positive regulation of T-helper 17 cell lineage commitment →	+0.191	+1.314	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Microtubule anchoring →	+0.086	+1.040	.005	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of macrophage proliferation →	+0.289	+1.365	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,345 associations by consensus.

Negative regulation of chromosome condensation by CBX6 expression — OVARY

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