CBX5

Across TCGA patient cohorts, CBX5 mutation is significantly associated with the RNA expression of many other genes, with 487 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBX5-associated genes across cancer lineages are MIR6803, RNA5SP200, and ATP2B2-IT1. Each is linked with CBX5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CBX5-to-partner and partner-to-CBX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6803 grouped by CBX5-low versus CBX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX5→partner) and Y-score (partner→CBX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6803 →	+0.300	+5.741	<.001	<.001	3	3
SKCM	RNA5SP200 →	+0.488	+7.816	<.001	.008	3	2
SKCM	ATP2B2-IT1 →	+0.074	+7.816	<.001	.008	3	2
HNSC	WBP1LP3 →	+0.144	+7.954	<.001	.008	3	1
UCEC	IGLV2-8 →	+2.214	+3.584	<.001	.003	3	1
UCEC	IGKV1D-12 →	+1.117	+4.010	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 487 associations by consensus.

MIR6803 by CBX5 expression — UCEC

Explore this box plot interactively →