CBX5

Across TCGA pan-cancer cohorts, CBX5 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CBX5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CBX5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CBX5 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRP, LIHC, and THCA are the cancer types where CBX5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CBX5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.968	<.001	10	view →
LIHC	Female	II,III,IV	+1.663	<.001	9	view →
THCA	All	All	−0.433	<.001	8	view →
HNSC	All	All	+0.683	<.001	6	view →
LUSC	All	All	+0.527	<.001	5	view →
LUAD	Male	All	+0.797	<.001	4	view →
COAD	Male	All	+0.566	.002	4	view →
BRCA	All	II,III,IV	+0.289	.004	4	view →
CHOL	All	All	+2.813	<.001	3	view →
KICH	All	All	−0.718	.001	3	view →
STAD	All	II,III,IV	+0.682	.019	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CBX5–KIRP

Open the KIRP breakdown →