CBX5

Across TCGA pan-cancer cohorts, CBX5 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CBX5 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher CBX5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CBX5 expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

UCS, LUAD, and HNSC are the cancer types where CBX5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	All	0.788	0.374	<.001	130	view →
LUAD	OS	Tertile	All	0.740	0.857	<.001	98	view →
HNSC	DFS	Median	All	0.723	0.525	<.001	91	view →
UVM	DFS	Tertile	II,III,IV	0.276	0.798	<.001	47	view →
KICH	DFS	Quartile	All	0.462	0.899	.004	39	view →
KIRC	DFS	Median	All	0.866	0.719	.001	36	view →
BLCA	DFS	Median	II,III,IV	0.459	0.559	.013	21	view →
LGG	OS	Tertile	All	0.703	0.920	<.001	21	view →
LIHC	OS	Quartile	All	0.665	0.799	.014	21	view →
THYM	DFS	Tertile	II,III,IV	0.964	0.570	.007	16	view →
UCEC	DFS	Tertile	All	0.794	0.885	.006	16	view →
PRAD	DFS	Quartile	All	0.951	0.867	.014	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CBX5–UCS (OS)

Open the UCS breakdown →